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The use of probiotics and the consequent increase in the short-chain fatty acids (SCFA) release, particularly butyrate, has been reported to enforce the gut barrier function as butyrate strengthens the barrier through increased expression of TJ components zonula occludens (ZO)-1, ZO-2, and cingulin (Bordin et al., 2004

Tesamorelin and Ipamorelin are synthetic peptides that stimulate the release of growth hormone, which can enhance muscle growth, facilitate fat loss, and improve overall health

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The authors recommend that future prospective trials further investigate the role of GLP-1 RAs in IIH management